The next step in preimplantation genetic screening.
Embryo quality is crucial for pregnancy success in IVF, and chromosomal normality is directly linked to embryo quality.
Chromosomal abnormalities can be identified through Preimplantation Genetic Testing for Aneuploidy (PGT-A), formerly known as Preimplantation Genetic Screening (PGS).
Embryo46, the new generation of PGT-A testing, goes beyond standard aneuploidy detection, providing a more accurate determination of chromosomal abnormalities in embryos.
Increased Pregnancy Rate
Reduced Miscarriage Rate
Enhanced Genetic Abnormality Detection
Improved Blastocyst Utilization Rate
Embryo46 offers advanced PGT-A capabilities that provide comprehensive insights into embryo health.
Checks if embryos have the correct number of chromosomes. Too many or too few can lead to failed implantation, miscarriage, or medical conditions like Down syndrome or Turner syndrome.
Looks for small missing or extra pieces of chromosomes. These can affect embryo development, leading to failed implantation, miscarriage, or genetic disorders.
Unique to Embryo46, this measures the total number of chromosome sets in an embryo. Normal embryos have two sets (diploidy), but some may have one set (haploidy) or three sets (triploidy), which will lead to implantation failure or miscarriage
Unique to Embryo46, this checks if all chromosomes in an embryo come from one parent instead of one from each parent. This can lead to failed implantation, miscarriage, or genetic disorders.
Studies show that using Embryo46 for PGT-A testing significantly increases pregnancy and live birth rates, offering higher resolution screening that does more than just aneuploidy detection. Embryo46 also identifies instances of small chromosomal segment variations (CNVs), haploidy, triploidy, and uniparental disomy (UPD), screening embryos and improving pregnancy success rates.
Embryo46 analyzes both individual chromosome numbers and the entire set for abnormalities. Ploidy abnormalities include haploidy and triploidy, which cause about 15-18% of miscarriages (source: Mutia K, et al. 2019). Using Embryo46 helps identify and select embryos with normal chromosome numbers, reducing miscarriage rates and the occurrence of genetic abnormalities.
| Testing Feature | Detection | Clinical Significance |
|---|---|---|
| Chromosomal Aneuploidy (Traditional PGS and Embryo46) | Abnormal copy of single or partial chromosomes | Affects pregnancy success rate, fetal health, and can lead to conditions like Down syndrome and Turner syndrome |
| Ploidy Quantification (Unique to Embryo46) | Abnormal number of entire chromosome sets | Usually leads to embryonic development failure and early miscarriage |
The total number of blastocysts and those suitable for implantation often differ. During embryo cultivation, embryologists observe pronuclei (PN) formation to assess fertilization:
Visual observation alone can't fully determine if 1PN and 3PN embryos have the correct chromosome number, leading to potential discarding of normal embryos. Data shows at least 10% of 1PN and 3PN embryos are actually diploid. Embryo46 accurately assesses chromosome sets, reducing the likelihood of discarding normal embryos and increasing usable blastocysts.
Compared to traditional PGT-A, Embryo46 provides higher resolution screening for small segment abnormalities, such as microdeletions or duplications. These insights help reduce the risk of implanting embryos with genetic issues. This is especially useful for parents with a history of genetic diseases.
Uniparental disomy (UPD) occurs when an embryo's chromosomes come entirely from one parent, rather than one chromosome from each parent. Though the incidence rate of UPD is only about 0.05%, it can lead to serious conditions like Angelman syndrome and Prader-Willi syndrome. Embryo46’s higher resolution screening is able to easily detect UPD.
| Traditional PGT-A | Embryo 46 |
|---|---|
| Detects segment deletions or duplications larger than 10Mb. Fails to identify smaller segment abnormalities (responsible for conditions like Angelman syndrome and Prader-Willi syndrome) | Detects segment deletions or duplications larger than 4Mb Identifies smaller segment abnormalities (responsible for conditions like Angelman syndrome and Prader-Willi syndrome) |
| Function | Traditional PGT-A | Embryo46 |
|---|---|---|
| Aneuploidy Detection | Yes | Yes |
| Haploidy and Triploidy Detection | No | Yes |
| Uniparental Disomy (UPD) Detection | No | Yes |
| Detection Resolution | Cannot detect segment abnormalities below 10MB | Can identify microdeletion and microduplications as small as 4MB |
Embryo46 benefits any patient undergoing IVF treatment, especially those who:
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Do you have more questions? Curious about how Embryo46 can increase your clinic's success rate? Head over to our Contact page, or set up a learning session with our Global Business Development Directory Tiffany Wang by reaching out directly: [email protected]
