ora™ is the first and only non-invasive endometrial receptivity test for determining the optimal time for embryo transfer.
ora™ assesses over 300 microRNA (miRNA) biomarkers in the blood that target more than 1,000 endometrial receptivity-related genes alongside a patient’s physiological conditions, making it the most comprehensive and accessible solution for identifying a patient’s personalized window of implantation (WOI).
ora™ analyzes miRNA biomarkers in the blood, removing the need for an invasive and uncomfortable endometrial biopsy procedure.
ora™ is able to account for both average and shortened post-receptive windows, meaning only one mock cycle is usually required. If your doctor collects the required blood samples during your first IVF cycle, the mock cycle can be avoided altogether.
ora™ as been shown to have > 95% accuracy in predicting endometrial receptivity, offering a stable solution with a more comfortable testing procedure.
ora™ analyzes close to 300 miRNA biomarkers that target over 700 confirmed endometrial receptivity-related genes, along with other physiological conditions to accurately identify the optimal time for embryo transfer.
Unlike other endometrial receptivity tests that use mRNA biomarkers, ora™’s miRNA-based technology gives accurate results from a simple blood sample. miRNA has the added benefit of being more stable than mRNA, meaning re-testing due to insufficient RNA occurs in <1% of cases.
The day 5 blood draw was found to be within the window of implantation (WOI), and is the optimal time for embryo transfer.
The blood was drawn before the WOI, and the endometrium was not yet ready for embryo transfer. It is recommended to delay the embryo transfer cycle by 24 hours.
The blood was drawn after the WOI, and the endometrium had passed the optimal time for embryo implantation. Based on the day 4 and day 5 blood draw results, it is recommended to move the embryo transfer time forward by 12 hours.
The blood was drawn after the WOI, and the endometrium has passed the optimal time for embryo implantation. Based on the day 4 and day 5 blood draw results, it is recommended to move the embryo transfer time forward by 24 hours.
* The need to re-test in the case of inconclusive results or invalid/insufficient RNA in the sample occurs in <1% of cases
ora™ can accurately identify the WOI of any patient, but not every patient needs endometrial receptivity testing. We recommended ora™ for those who meet any of the following conditions:
You will undergo a standard IVF cycle or mock cycle to create the optimal IVF conditions.
Your doctor will collect a blood sample from you on day 4* and day 5 of your menstrual cycle of progesterone administration, or on day 6* and day 7 for natural cycles (after LH surge or hCG trigger shot).
Your sample will be sent to an ora™ laboratory for processing and data analysis.
An ora™ analysis report will be provided to your doctor, informing them of the optimal time for embryo transfer.
*An additional blood draw on day 4 of HRT cycles or day 6 of natural cycles is dependent on your physician’s practice and may vary between clinics. In the case of a single blood draw on day 5 only, the chances of needing an additional mock cycle will increase.
Endometrial receptivity testing can help improve your chances of a successful IVF pregnancy, but it’s a decision that must be made in tandem with the doctor overseeing your fertility journey. Discuss with them today if you think ora™ might be right for you.
In vitro fertilization is a form of assisted reproductive technology where an egg is fertilized with sperm in a laboratory environment. Through a combination of medication and surgical procedures, eggs are retrieved, fertilized, and implanted for reproduction. A typical cycle of IVF takes 2 to 3 weeks.
Endometrial receptivity refers to the status of the endometrium in relation to its ability to accept an embryo for implantation. There is a window of 2 to 3 days around the middle of your menstrual cycle, when the mucus membrane lining the uterus, the endometrium, is at the ideal thickness and consistency for embryo implantation to happen. This interval of receptivity is commonly called the window of implantation (WOI).
The interval of receptivity, also known as the window of implantation, typically occurs between days 19 and 21 of the menstrual cycle of fertile women. Large-scale studies show that 30% of infertility patients have a displaced WOI. One of the main causes of implantation failure is the lack of synchronization between the embryo and endometrium.
